It has been proposed that social cohesion in gregarious animals is reinforced both by a positive affective state induced by social interactions and by the prevention of a negative state that would be caused Minimalist Cases by social separation.Opioids that bind to mu opioid receptors (MORs) act in numerous brain regions to induce positive and to r
Yoshiaki Tanaka,1 Fumihiko Toyoda,1 Machiko Shimmura-Tomita,1 Nozomi Kinoshita,1 Hiroko Takano,1 Yoh Dobashi,2 Shigeki Yamada,2 Hiroto Obata,3 Akihiro Kakehashi1 1Department of Ophthalmology, Saitama Medical Center, Jichi Medical University, Saitama, Japan; 2Department of Pathology, Saitama Medical Center, Jichi Medical University, Saitama, Japan;
Osteosarcoma is a highly aggressive cancer common in children and adolescents.There is still a lack of effective treatments for metastatic or recurrent osteosarcoma.The role of long non-coding RNAs (lncRNAs) in osteosarcoma has gradually attracted attention.Here, we identified lncRNAs that were abnormally expressed in metastatic osteosarcoma throug
BackgroundAbout 20% of patients with common variable immunodeficiency (CVID) suffer from interstitial lung disease (ILD) as part of a systemic immune dysregulation.Current understanding suggests a role of B cells in the pathogenesis based on histology and increased levels of BAFF and IgM associated with active disease corroborated by several report
In recent decades, parallel literature has documented the magnitudes and effects of teacher turnover and Chromium the impact of state school finance reforms (SFRs).In this paper, we examine SFRs as possible mechanisms to improve teacher salary, turnover, and job satisfaction by using nationally representative data from 2000 to 2016 and leveraging v